THE NEUROBIOLOGICAL MECHANISM UNDERLYING HYPOTHALAMIC GNRH PULSE GENERATION: THE ROLE OF KISSPEPTIN NEURONS IN THE ARCUATE NUCLEUS [VERSION 1; PEER REVIEW: 4 APPROVED]

This review recounts the origins and development of the concept of the hypothalamic gonadotropin-releasing hormone (GnRH) pulse generator.It starts in the late 1960s when striking rhythmic episodes of luteinizing hormone secretion, as reflected by circulating concentrations of this gonadotropin, were first observed in monkeys and ends in the presen

Permeability is one of the most important reservoir rock parameters in petroleum engineering, reservoir, and exploitation.This parameter causes the movement of hydrocarbon reserves in the reservoir rock.Therefore, it is an important parameter from the economic point of view because it greatly whirlwind direct2 impacts the amount of extraction from

A healthy crop growth ensures a good biomass development for optimal yield amounts and qualities.This can only be achieved with sufficient knowledge about field conditions.In this study we investigated the performance of optical sensors in large field trails, to predict yield and biomass characteristics.This publication investigated how information

Background and objectiveGlycation is a common post-transcriptional modification of proteins.Previous studies have shown that advanced glycation end modified transferrin (AGE-Tf) levels in diabetic rat kidney tissues were increased; however, its role in diabetic nephropathy remains unclear.In this study, differences in glycation degree and Tf sites

Background: The incidence of osteosarcoma reached 16.8 cases annually at dr.Cipto Mangunkusumo Hospital in 1995-2008.Previous studies suggested that prolonged neoadjuvant chemotherapy followed by delayed surgery improves the clinical outcome.Prolonged neoadjuvant chemotherapy followed by delayed surgery commonly occurs in Indonesia, as diagnostic i